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Gestational Diabetes Induces Pancreatic Beta-Cells Apoptosis in Adult Rat Offspring International Journal of Morphology
Nazari,Zahra; Nabiuni,Mohammad; Ghaffari,Soraya; Saeidi,Mohsen; Shahriyari,Alireza; Golalipour,Mohammad Jafar.
Several studies indicated that pancreatic ß-cell death occurs in both type 1 and type 2 diabetes. This experimental study was designed to determine the effect of gestational diabetes on the ß-cells in 16-week-old rat offspring. By this aim, adult Wistar rats aged 10-12 weeks were randomly allocated in control and diabetic groups. The diabetic group received 40 mg/kg/body weight of streptozotocin (STZ) on day zero of gestation. After delivery, diabetic offspring of GDM mothers and controls at the age of 16 weeks were sacrificed and pancreases harvested and fixed. The number of ß-cells and were counted by Gomori's method staining. Also, apoptosis in pancreas tissue of diabetic and control offspring was detected by TUNEL assay. Results showed a significant...
Tipo: Journal article Palavras-chave: Gestational diabetes mellitus; Pancreatic islets (Langerhans); SS-cell; Apoptosis; Rat offspring.
Ano: 2017 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000100003
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Potentiation of a novel palladium (II) complex lethality with bee venom on the human T-cell acute lymphoblastic leukemia cell line (MOLT-4) J. Venom. Anim. Toxins incl. Trop. Dis.
Safaeinejad,Zahra; Mohammad Nabiuni,; Nazari,Zahra.
Background : Although honeybee venom (BV) has been reported to induce apoptosis in different types of cancerous cells, its synergistic effects with customary anti-cancer drugs remain largely unknown. In the present study, we evaluated the cytotoxic effect of BV alone (as a natural product) and the synergistic cytological effects of this component in combination with [Pd (bpy) (Pi-Pydtc)]NO3 - a novel palladium complex on human T-cell lymphoblastic leukemia cells. To investigate the cytotoxic effect of the BV alone and in combination with palladium complex on MOLT-4 cells MTT assay was performed. In order to determine the apoptotic effects of BV separately and in combination with Pd (II) complex on these cells and its ability to induce apoptosis,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Apoptosis; Bee venoms; Cytotoxicity; MOLT-4 cell line; Pd (II) complex.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992013000100315
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The Effect of Gestational Diabetes Mellitus on Sciatic Nerve in Adult Offspring Rats International Journal of Morphology
Ameri,Mehdi; Ghafari,Soraya; Nazari,Zahra; Mehdizadeh,Mehdi; Shekari,Majid Asadi; Golalipour,Mohammadjafar.
Gestational diabetes mellitus (GDM) is one form of diabetes affect approximately 7 % of pregnancies. Diabetic peripheral neuropathy (DPN) is a common complication of diabetes that is associated with loss of nerve fibers, myelin abnormalities and significant decrease in the expression of myelin basic protein (MBP) in peripheral nerves. This study was done to determine the effect of induced diabetes during pregnancy on sciatic nerve in adult rat offspring. In this study, wistar rats' dams were allocated to control and diabetic groups. Diabetic rats were received 40 mg/kg/body weight of streptozotocin (STZ) on the first day of gestation. Six offspring of each group were randomly selected on 12 weeks postnatal and histopathological changes in their nerve...
Tipo: Journal article Palavras-chave: Gestational diabetes mellitus; Sciatic nerve; Myelin basic protein; Schwannocytus (Schwann cell).
Ano: 2017 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000100026
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